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The Evusheld Fourth Vaccine Conundrum

When I got my first dose of Evusheld on February 15th here in Western New York State, the talk about the 2nd booster was a very quiet buzz around here. I had also had my first visit with an immunologist and explained that I was getting Evusheld, and he informally suggested I wait to get 2nd booster.

Now there is better advice. If you are still fighting to get the Evusheld jab and are considering booster, do the booster first. Wait at least two weeks to get Evusheld (and make sure the provider is up to date on the correct dosage) as per the Manufacturer information agreed with the FDA:

“Individuals who have received a COVID-19 vaccine, EVUSHELD should be administered at least two weeks after vaccination.” SPC

Otherwise, let Evusheld do its job and wait….perhaps as long as 5 months to get booster.

Here is an excerpt from a Q and A by Dr. Susan LeClair on her opinion of why we would want the booster first.

———- Forwarded message ———
From: Susan LECLAIR <sleclair@umassd.edu>
Date: Sun, Apr 3, 2022, 10:50 AM
Subject: Re: [CLLSLL] How soon to do a second booster after evusheld?
To: <CLLSLL@groups.io>

Mark, Evusheld does not produce antibodies. It IS preformed, quality controlled antibodies.

If you take a booster which is virus pieces, you are asking your body to make antibodies to fight the virus of which the pieces are part. If you then get Evusheld, you are simply adding antibodies.

If you you take the evusheld first and then the vaccine, you use up the evusheld binding to the virus pieces this is counterproductive.

Susan Leclair.

Dr. Susan Leclair is a retired chancellor professor from the Department of Medical Laboratory Science at the University of Massachusetts Dartmouth. Dr. Leclair is also a senior associate at the UMass Center for Molecular Diagnostics. She has professional lab experience for more than 40 years, and her clinical interests include clinical hematology and oncology, human genetics and bioethics. She regularly participates in Patient Power events and is a great source of information for the blood cancer community. See all of her published videos and articles on Patient Power here.

Please note that at the time of writing this article, I could find no studies done to back up Dr. Leclair’s thought process from that Q & A excerpt; however, I included it as I found other recommendations (without explanation) that were similar. Her answer is specific, and with her credentials and experience, I feel that it is a correct answer.

My position is that Evusheld is still the salvation for the immunocompromised! And it is still sitting on shelves, unused.

The CNN article from March 24th exposed that there is a lot of Evusheld in the United States in the most unlikely places and I confirmed with my local source that the expiration date on the original batches shipped to various facilities is most likely July 31st. If you are still trying to get Evusheld, there is plenty of evidence you can use in your “argument” and you can also include this link from Astra Zeneca (which talks about its effectiveness with current varients) in trying to explain this to your physician to get a prescription.

There is a lot of misinformation and ignorance on this topic. We can gently point people to the right information and hopefully will get the results we need. In the meantime, I hope you all are enjoying better weather and are getting out a bit.

This information was current at time of publication and is the opinion of the author, not Blood Cancer Uncensored.

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Lisa Wiest
  • Lisa Wiest
  • Blood cancer DX 1/5/17 (CLL). I am a nobody in the grand scheme. I can choose to be overwhelmed by my circumstances and all the "whys" and "what fors" or I can surrender. I choose surrender. By the grace of God through Jesus Christ, I have become a Child of God. Being on His team is the only sure thing in this life. This is my journey. A peek into my joys, fears, and passions. Come along with me and smell the flowers along the way. ~Lisa You can e-mail Lisa here.