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Astra Zeneca’s Evusheld preventative COVID19 Monoclonal Antibody injection licensed in UK. But so far the NHS refuses to pay for it!

Finally many months after the USA, the UK regulator has approved this product designed for patients like me with blood cancer and other causes of immune compromise. Perhaps we will begin to feel more safe and less abandoned. 

One dose of this injection can provide months of a similar level of preventative shielding against COVID19 to that which most people get when the vaccines do work.

No patients in the clinical trial died of COVID19 after receiving this injection. But in a group half the size five people on placebo did die

https://www.astrazeneca.com/media-centre/press-releases/2022/astrazenecas-antibody-combination-evusheld-authorised-for-use-in-great-britain-for-pre-exposure-prophylaxis-prevention-of-covid-19.html

People with immune compromise are still dying of COVID19 so it is essential that the NHS rapidly agrees to fund this treatment, and rolls it out in a fair and easy to access way, and that enough doses are purchased. 

UPDATE: it turns out that our Government and the NHS cares so little about the immunocompromised being able to LIVE with less fear of dying from Covid-19 that they CANCELLED an order for a million doses! See https://www.fiercebiotech.com/biotech/as-data-nears-u-k-rethinks-astrazeneca-covid-19-antibody-deal

It is also crucial that patients are warned that vaccines may not have worked for them, tested to see if they have had an antibody response, given this new treatment as a protection, and allowed to keep themselves safe by for example working from home. But it is also vital that antiviral treatments must be made more easily available for any who do still get covid19 despite being protected by these monoclonal antibodies.

Sign our petition 

Sign our petition to fund Evusheld for blood cancer and other causes of immune compromise. These preventative antibodies massively reduce the risk of Covid19 hospitalisations and death

I am concerned given recent fiascos regarding antivirals, extra vaccine doses, and priority PCR kits, that this roll out will be far from smooth and this would be a good time to write to your MP, asking why there is no corresponding announcement of funding for the treatment to be given immediately to all of us shielders desperate to get on with our lives!

Hugh Montgomery, principle investigator of the Provent trial and professor of intensive care medicine at University College London, was quoted in the BMJ as follows, “Sensible behaviours combined with vaccination offer excellent protection from severe illness for most of the UK. But for some our new freedoms impose a prison sentence: they do not mount adequate antibody responses to vaccines, meaning that they are more vulnerable to SARS-CoV-2 infection and to more serious consequences from it. For them, one option is to receive the antibody through an intramuscular injection.” He added, “Side effects seem mild and few and protection long lasting.”

 

BMJ (includes reply from Adrian)

“I write as both a doctor and a blood cancer patient. You rightly quote that for many of us the new freedoms are a prison sentence. After two years of near solitary confinement for many the great news of this regulatory approval was elating but you neglected to mention the other side of this good news story which is crushing.

Our Government and the NHS have cancelled their order for a million doses of this treatment. It seems providing those who do not respond to vaccines with an antibody shield so we too can live with COVID-19 is not a priority. So we will likely continue to be over represented in deaths alongside other patients with immune compromise. It feels unfair of you to offer hope without checking if the funding is in place which it isn’t. There’s many depressed patients now feeling more abandoned by society to eventually catch and in some cases die of COVID-19. I hope I am not one of the deaths which could have been prevented by this wonderful treatment.”

See also
http://bloodcanceruncensored.com/uk-nhs-sends-out-another-batch-of-covid19-treatment-emails
 
https://bloodcanceruncensored.com/had-evusheld-you-need-a-top-up-dose-asap-to-increase-protection-against-new-variants/
https://bloodcanceruncensored.com/thrown-to-the-wolves-by-the-uk-the-end-of-all-covid-protections-and-no-more-tests-except-for-those-on-the-new-at-greatest-risk-list-doinotmatter-bloodcancer-immunocompromised/ https://bloodcanceruncensored.com/regeneron-covid-monoclonal-antibodies-finally-approved-in-the-uk-az-antibodies-prevented-all-severe-infections-and-deaths/ https://bloodcanceruncensored.com/international-covid-19-blood-cancer-coalition-icbcc-patient-impact-and-recommendations-protecting-immunocompromised-blood-cancer-patients-during-the-covid-19-pandemic/ https://bloodcanceruncensored.com/international-covid-19-blood-cancer-coalition-icbcc-patient-impact-and-recommendations-protecting-immunocompromised-blood-cancer-patients-during-the-covid-19-pandemic/ https://bloodcanceruncensored.com/is-covid19-risk-to-blood-cancer-patients-now-at-all-time-high/ https://bloodcanceruncensored.com/is-covid19-risk-to-blood-cancer-patients-now-at-all-time-high/

The MHRA press release stated

A new medicine, Evusheld (tixagevimab/cilgavimab), has today been authorised for COVID-19 prevention by the Medicines and Healthcare products Regulatory Agency (MHRA) after meeting the UK regulatory standards of safety, quality and effectiveness

The decision to grant approval for this treatment was endorsed by the government’s independent expert scientific advisory body, the Commission on Human Medicines, after carefully reviewing the evidence.

Developed by AstraZeneca, Evusheld is a combination of two long-acting antibodies that works by binding to the spike protein on the outside of the SARS-CoV-2 virus, the virus that causes COVID-19. This in turn prevents the virus from attaching to and entering human cells.

Evusheld is authorised to be used before being exposed to the risk of COVID-19 infection in order to prevent disease (known as ‘pre-exposure prophylaxis’).

For most people, the best way to prevent infection is vaccination. Evusheld has been approved for use in adults who are unlikely to mount an immune response from COVID-19 vaccination or for whom vaccination is not recommended.

Recipients should not be currently infected with or had recent known exposure to a person infected with the COVID-19 virus.

A single dose of the two medicines, tixagevimab and cilgavimab, should be given as two injections into a muscle by a healthcare professional.

In a clinical trial in adults, Evusheld was found to reduce the risk of developing symptomatic COVID-19 by 77%, with protection from the virus continuing for at least 6 months following a single dose.

READ THE REST

Gemma Peters, Chief Executive of Blood Cancer UK, said: “We welcome the MHRA’s approval of Evusheld and we hope it means people with blood cancer who may not have responded well to the vaccines could have another option available to them in the future. The high infection rate has meant many of them have felt left behind as the rest of society gets back to normal, and Evusheld offers them hope of getting a similar level of protection against Covid as most of the population have already got from the vaccines.

“But while today’s approval is welcome news, the Government is yet to set out how it plans to use Evusheld. For some time, we have been urging the Government to set out its approach to using preventative treatments for people who have not responded well to the vaccines, and it is disappointing that it has not yet done so. We hope the MHRA’s approval of Evusheld will prompt a sense of government urgency on this that has so far been lacking. Many people with blood cancer have now spent almost two years avoiding social interaction – the Government needs to do more to support them to be able to start getting back to normal.

“It is also important that people with blood cancer understand that while Evusheld is a potentially game changing treatment, there are still unanswered questions about it. We are confident it gives good protection against previous Covid variants and there is reason to think it will also protect against Omicron, but we have not yet seen real-world data on how much protection it gives against Omicron, or for how long. We are pleased to hear the MHRA plans to keep monitoring this, as it is vital that those who have Evusheld are kept up to date on this, so they can make their own informed decisions about how they live their lives.”

Astra Zeneca when asked to confirm if they have a contract with the UK to fund their product said

““DHSC have not procured any stock for the UK at this time. Evusheld is being supplied and used in multiple countries and we will apply our best endeavours to supply the UK Government in the event we are requested to.”

Astra Zeneca UK

A Department of Health and Social Care spokesperson said:

“The UK has so far identified and secured multiple life-saving COVID-19 treatments for NHS patients which have helped thousands of people.

This is welcome news from our renowned medicines regulator and we will continue to closely monitor investigations into the treatment’s effectiveness against new variants.”

The Therapeutics Taskforce is actively engaging with AstraZeneca and will study product details carefully ahead of further decisions.”

Department of Health and SOCIAL CARE

 

Learn More

 

Watch Blood Cancer UK for updates

 

The company also shared some more of the clinical data in their own press release.

Patient Information Leaflet for Evusheld

Summary of Product Characteristics for Evusheld

iNews (includes quote from Adrian)

 

Daily Mail

Guardian

BMJ (includes reply from Adrian)

“I write as both a doctor and a blood cancer patient. You rightly quote that for many of us the new freedoms are a prison sentence. After two years of near solitary confinement for many the great news of this regulatory approval was elating but you neglected to mention the other side of this good news story which is crushing.

Our Government and the NHS have cancelled their order for a million doses of this treatment. It seems providing those who do not respond to vaccines with an antibody shield so we too can live with COVID-19 is not a priority. So we will likely continue to be over represented in deaths alongside other patients with immune compromise. It feels unfair of you to offer hope without checking if the funding is in place which it isn’t. There’s many depressed patients now feeling more abandoned by society to eventually catch and in some cases die of COVID-19. I hope I am not one of the deaths which could have been prevented by this wonderful treatment.”

See also
http://bloodcanceruncensored.com/uk-nhs-sends-out-another-batch-of-covid19-treatment-emails
 
https://bloodcanceruncensored.com/had-evusheld-you-need-a-top-up-dose-asap-to-increase-protection-against-new-variants/
https://bloodcanceruncensored.com/thrown-to-the-wolves-by-the-uk-the-end-of-all-covid-protections-and-no-more-tests-except-for-those-on-the-new-at-greatest-risk-list-doinotmatter-bloodcancer-immunocompromised/ https://bloodcanceruncensored.com/regeneron-covid-monoclonal-antibodies-finally-approved-in-the-uk-az-antibodies-prevented-all-severe-infections-and-deaths/ https://bloodcanceruncensored.com/international-covid-19-blood-cancer-coalition-icbcc-patient-impact-and-recommendations-protecting-immunocompromised-blood-cancer-patients-during-the-covid-19-pandemic/ https://bloodcanceruncensored.com/international-covid-19-blood-cancer-coalition-icbcc-patient-impact-and-recommendations-protecting-immunocompromised-blood-cancer-patients-during-the-covid-19-pandemic/ https://bloodcanceruncensored.com/is-covid19-risk-to-blood-cancer-patients-now-at-all-time-high/ https://bloodcanceruncensored.com/is-covid19-risk-to-blood-cancer-patients-now-at-all-time-high/

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Adrian Warnock
  • Adrian Warnock
  • Dr. Adrian Warnock is a medical doctor and clinical research expert who was himself diagnosed with blood cancer in May 2017. Adrian worked in the pharmaceutical industry for fifteen years helping to run the clinical trials that bring us new medicines and communicate the results. Before this he practised in the UK’s National Health Service (NHS), as a psychiatrist, for eight years.

    Adrian is a published author, the founder of Blood Cancer Uncensored, and has written a Christian blog since 2003 at Patheos. He is passionate about learning how to approach suffering with hope and compassion. Adrian's articles are not medical advice and he is not a haematologist or blood cancer doctor. Always seek individualised advice from your health care professionals. You can e-mail Adrian here.

Adrian Warnock