Today Joy introduces us to a fascinating paper about the way different mutations are involved in the formation of MPNs and their risk of transformation into more aggressive types of blood cancer. It is important to understand that there is a family tree of different types of blood cancer.

What is your primary mutation? Do you know your non-driver mutation(s)? This is a super interesting, yet technical paper regarding primary and non-driver (secondary) mutations. Check out the secondary mutations listing in table 1. (Sorry I can’t load it here for some reason) ASXL1 and EZH2 have a greater risk of transformation to AML and DNMT3A and IDH1/2 have low survival in MF. Regarding primary mutations, those that are triple-negative have a higher overall rate of disease progression if post ET but mild otherwise. There is also a fascinating study regarding different medications and their specific mutation implications. I am sure more info will come out soon on this and if someone can break this all down for us it will be appreciated!

READ THE ARTICLE HERE

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