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Asciminib (Scemblix) STAMP Inhibitor for Certain Chronic Myeloid Leukemia Patients Approved by FDA

This information is current as of the publication date.

This news is a result of individuals like you and I participating in a medical drug trial. This trial was called ASCEMBL. Thank you to all of the folks who participated. From time to time Blood Cancer Uncensored attempts to highlight trials that might be useful to our members or include links to organizations who have asked us to share information about research and medical trials. Use this link to find trials in the United States or United Kingdom or Canada, for example as these are updated frequently.

Here is the press release regarding the approval of Asciminib:

https://www.medpagetoday.com/hematologyoncology/leukemia/95370?xid=nl_mpt_DHE_2021-11-02&eun=g1855899d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20Top%20Cat%20HeC%20%202021-11-02&utm_term=NL_Daily_DHE_dual-gmail-definition

What is TKI therapy?

It is notable that this is different than the BTK inhibitors used in other blood cancer treatments.

What makes a STAMP inhibitor different than just a TKI?

This video published on ecancer gives an excellent explanation.

https://ecancer.org/en/video/9389-first-in-class-stamp-inhibitor-asciminib-in-patients-with-cml-harbouring-the-t315i-mutation

This information is very important as patients with the T3151 mutation with this diagnosis historically had poor expected outcomes from the traditional treatment. If you have CML and this mutation, or if you have had poor response to traditional treatment, ask your doctor if you qualify for this treatment.

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Lisa Wiest
  • Lisa Wiest
  • Blood cancer DX 1/5/17 (CLL). I am a nobody in the grand scheme. I can choose to be overwhelmed by my circumstances and all the "whys" and "what fors" or I can surrender. I choose surrender. By the grace of God through Jesus Christ, I have become a Child of God. Being on His team is the only sure thing in this life. This is my journey. A peek into my joys, fears, and passions. Come along with me and smell the flowers along the way. ~Lisa You can e-mail Lisa here.